Oral plasmablastic lymphoma as the first manifestation of AIDS*
نویسندگان
چکیده
Plasmablastic lymphoma is a non-Hodgkin lymphoma characterized by its plasmacytic differentiation and predilection for the oral cavity. It is among the lymphomas most commonly associated with AIDS. This report details a case of a HIV-positive patient with a 1-month history of an exophytic mass in the gingival area of the upper left quadrant. The diagnosis of plasmablastic lymphoma was made based on its histopathological and immunophenotypical features. She was treated with chemotherapy followed by autologous hematopoietic stem cell transplantation. Despite complete resolution of the lesion, the patient died of cardiorespiratory arrest. This case illustrates plasmablastic lymphoma as the first clinical manifestation of AIDS, highlighting the importance of differentiating between a potentially malignant lesion and other pathologic processes.
منابع مشابه
An Aggressive Plasmablastic Lymphoma of the Oral Cavity as Primary Manifestation of Acquired Immunodeficiency Syndrome: Case Report and Literature Review
Introduction Plasmablastic lymphoma is a rare entity that was first described in the jaws and the oral cavity of patients with human immunodeficiency virus (HIV) and acquired immunodeficiency syndrome (AIDS). Plasmablastic lymphoma is considered as a diffuse, large, B-cell lymphoma with a unique phenotype and a predilection for the oral cavity. Objective The authors describe a case of an aggres...
متن کاملRare AIDS-associated plasmablastic lymphoma as the initial presentation of AIDS.
Non-Hodgkin lymphoma (NHL) is the sixth leading cause of cancer death in the United States and accounts for 2–3% of primary neoplasms.1 Plasmablastic lymphoma (PBL) is a rare AIDS-associated NHL of diffuse large B-cell lymphoma (DLBCL) type. It typically presents in HIV infection in the oral cavity.2 Here we discuss a case of a young woman who presented with PBL in the rectum as the initial man...
متن کاملAIDS-related plasmablastic lymphoma of the oral cavity associated with an IGH/MYC translocation--treatment with autologous stem-cell transplantation in a patient with severe haemophilia-A.
Plasmablastic lymphoma is an AIDS related lymphoma that continues to have a poor prognosis despite significant advances in the management of HIV and lymphoproliferative diseases. In part this has been due to limited insights into the biology of this disease and the molecular mechanisms of oncogenesis. To date molecular abnormalities have not been described in plasmablastic lymphoma, and its agg...
متن کاملEditorial comment: plasmablastic lymphoma--a diagnostic and therapeutic puzzle.
Plasmablastic lymphoma is a unique AIDS-related lymphoma, which was first described in the jaws and oral cavity of HIV-infected persons about a decade ago.4,5 Awareness of this distinctive lymphoma can prevent misdiagnosis by the clinician (eg, as odontogenic cellulitis) or the pathologist (eg, as a nonlymphoid malignancy). Since the original reports of plasmablastic lymphoma, it has been descr...
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Plasmablastic lymphoma is a rare and a relatively new entity that was first described in the jaws and the oral cavity of HIV-AIDS patients. We report a case of plasmablastic lymphoma involving the liver in an AIDS patient. Plasmablastic lymphoma is considered a diffuse large B-cell lymphoma with a unique phenotype and predilection for the oral cavity. The case presented had a unique hepatic les...
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